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KMID : 0369819800100020201
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Jorunal of Korean Pharmaceutical Sciences
1980 Volume.10 No. 2 p.201 ~ p.207
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Studies on the Sustaining Availability of Drug with Acrylic - methacrylic Ester Copolymer Films
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김근혁/Kim KH
권종원/민신홍/이상희/김용배/Kwon JW/Min SH/Rhee SH/Kim YB
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Abstract
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Spherical granules obtained by extrusion-spheronization processing were used to prepare sustained release spherical granules by pan coating method. Acrylic-methacrylic ester copolymer and mixtures of ethylcellulose, cellulose acetate phthalate and hydroxypropylmethylcellulose were utilized for prolongation of drug release from spherical granules containing acetaminophen as a model drug. In vitro release rate of sustained release spherical granules was investigated by varying the quantity of release retardants applied. Dissolution studies revealed that sustained release spherical granules coated with acrylic-methacrylic ester copolymer showed more protracted release than those granules coated with ethylcellulose mixtures.
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